In 2025, assisted reproductive technology will enter the era of precise regulation. The cost of a single cycle of first-generation (IVF-ET), second-generation (ICSI), and third-generation (PGT) IVF babies will range from 30,000 to 180,000 yuan. The core of the cost difference stems from technical complexity, depth of genetic screening and hospital level. Individual physiological conditions and regional policies further widen the price range. This article combines the latest quotations from the top ten reproductive centers in the country to provide families with a panoramic cost decision-making framework.
1. Comparison of intergenerational costs of technology: from basic fertilization to gene editing
1. Generation IVF-ET

Applicable population: Female factors such as fallopian tube blockage and ovulation disorders are infertile

.▶ Target population: Women with infertility issues caused by blocked fallopian tubes, ovulation disorders, and other female-related factors.
▶ Cost range: 30,000–50,000 yuan.
Preoperative examination (chromosome/infectious disease screening): 3000 - 8000yuan
Ovulation promotion drugs (domestic 5000 yuan/imported 20,000 yuan): accounting for 30%-50% of thecost
Oocyte retrieval + embryo culture + transfer: 15,000 - 25,000yuan
Hidden costs: embryo freezing (1300 yuan/tube/year), pouch maintenance fee (4000 yuan).
Hidden costs include embryo freezing (1,300 yuan per tube per year) and blastocyst culture fees (4,000 yuan).

Applicable population: Male infertility such as severe oligospermia and obstructive azoospermia

.▶ Target population: Men with severe oligoasthenospermia, obstructive azoospermia, and other types of male infertility.
▶ Cost range: 50,000–80,000 yuan.
Single sperm injection: increased by 4000 - 8000yuan
Microsperm harvesting (testicular puncture): 27,000 yuan
Technical limitations: Genetic risks cannot be avoided and three generations of technology are needed to supplement them.
Technical limitations: It is impossible to avoid genetic risks; third-generation technologies are needed to address these issues.
3. Third-generation IVF (PGT)

Applicable population: carriers of genetic diseases, repeated miscarriages, and elderly people (> 38 years old).
Cost range: 80,000 - 150,000 yuan.
Core premium itemsPreimplantation Genetic Testing of Embryo (PGT-A/PGT-M): 20,000 - 100,000 yuan (billed based on the number of embryos, 3000 - 5000 yuan per embryo)
Whole genome sequencing upgrade: an additional 50,000 - 80,000 yuanBut the cost is three times that of a generation of test tubes.


2. Five core variables of expense fluctuations1. Individual physiological differences
Age: Women ≥ 38 years old have a 30% increase in the amount of ovulation promotion medication, and the cost has increased by 10,000 - 20,000 yuanSperm quality: Severe severe oligospermia requires microscopic sperm collection, and the cost increases by 27,000 yuan
Ovarian response: The single-cycle failure rate in patients with premature aging exceeds 50%, and the cost of multiple promotion of ovulation is doubled.


2. Drug and regimen selectionImported excretion promoting drugs (Ruofen) are 2 - 3 times more expensive than domestic drugs
The natural cycle plan (without anti-excretion drugs) can save 15,000 yuan, but it is suitable for less than 10% of the population.

3. Regional and hospital levelsThe top three in first-tier cities are 15%-20% more expensive than those in second-tier and third-tier cities (such as Beijing Xiehe VS Local Reproductive Center).

4. Technical add-ons
Repeated freezing and thawing of embryos: each time increased by 2000 - 3000 yuan.

3. Among the top ten national centers of biological development (2025 Single-week period) name of hospital t Generation 1/2 fees Generation 3 fees

Beijing t 35,000 - 60,000 t Changsha Changsha 100,000 - 180,000 t Shanghai Renji Hospital Shanghai

r 120,000 - 150,000 t Shandong Dong University Affiliated Hospital n 35,000 - 50,000 30,000 - 120,000 t Guangzhou 40,000 - 60,000 Guangzhou

n Sichuan Huaxi Second Medical Hospital n 100,000 left and right Nanjing Drum Tower Hospital 35,000 - 60,000 70,000 - 130,000-r

n Chongqing First Affiliated Hospital of Zhengzhou University Zhengzhou r 40,000 - 70,000 Zhejiang University Gynecology and Gynecology Hospital

Hangzhou 31,000 - 51,000 r Data explanationThe first/second generation expenses include elimination promotion drugs, egg retrieval and transplantation, and basic cultureThe cost of three generations is superimposed on the cost of embryo genetic testing, charged according to the number of embryos (3000 - 5000 yuan per embryo)

Beijing Union Medical College, Shanghai Ruijin and other hospitals due to the number limit policy (such as daily limit of 15 groups) costs fluctuate greatly.

4. Cost optimization strategy: four-step method for scientific cost controlY chromosome microdeletion → directly select three generations (avoid multiple failures and loss).



2. Stepped genetic screeningBasic PGT-A screening for chromosomal abnormalities (20,000 - 30,000), and then upgraded PGT-M screening for single gene diseases (30,000 + provinces).

3. Public hospitals + promotion cycleThe top three public companies are 15%-20% higher than those in private provinces (for example, Beijing 301 Hospital regularly opens drug subsidies)
Lock in the reproductive department discount season from September to November, and some institutions waive the annual fee for embryo freezing.


Adjust BMI (18.5 - 24) and supplement zinc and selenium (improve egg quality by 20%) 3 months in advancePeople with premature ovarian failure should use a microstimulation regimen (the cost is reduced by 30%, and the number of cycles needs to be increased).

5. Balancing cost and maternity securityAn analysis of the cost of IVF in 2025 reveals that the first generation is cost-effective, the second generation is male infertility, and the third generation is resistant to inheritance.
Behind the intergenerational technology price difference are advances in reproductive safety and medical precision. It is recommended that couples choose a formal reproductive center to formulate personalized plans based on medical indications (such as main causes of infertility, genetic risks) and economic budget, so that every investment can become an effective investment in new life.