1. What is third-generation IVF technology (PGT)?

The three-generation IVF, medically known as Preimplantation Genetic Testing (PGT), is based on the first-generation (IVF) or second-generation (ICSI) IVF technology and adds embryonic chromosome and genetic testing links. Simply put, before the embryo is transferred to the mother's uterus, the embryo is first genetically analyzed and healthy embryos with normal chromosomes and no genetic diseases are selected for transfer.

According to different testing purposes, PGT is mainly divided into three categories

.PGT-A (original PGS)pre-implantation embryo aneuploidy genetic screening, which mainly detects whether the number of chromosomes in the embryo is normal and screens for abnormal numbers of 23 pairs of chromosomes

.PGT-M (original PGD)pre-implantation embryo single-gene genetic disease testing, aiming at diagnosis of clear single-gene genetic diseases and blocking the transmission of pathogenic genes

.PGT-SRpre-implantation chromosome structural variation genetic testing, screening for structural abnormalities such as chromosome translocations and inversion

. The

three-generation test tube is not an upgrade relationship of "one generation stronger than the next", but a technical route for different indications. Which generation of test tubes to choose needs to be comprehensively judged according to the specific physical condition of the patient, the cause of infertility, genetic risk and other factors. Lelaiwa Consulting Service Center Pregnancy Center is equipped with professional medical consultants who recommend the most suitable technical solution according to each customer's examination report and fertility needs.

Six core advantages of second and third generation IVF technology

In natural conception and ordinary IVF cycles, about 50%-70% of embryos will not be successfully implanted due to chromosomal abnormalities, which is also the main reason for many patients with repeated implantation failure. Third generation IVF uses PGT-A technology to select embryos with normal chromosome numbers for transfer

. This advantage is especially obvious for elderly women over 35 years old. With age, the rate of chromosome abnormalities in eggs increases significantly: about 20% at 30 years old, about 40% at 35 years old, and as high as more than 80% at 40 years old. Screening normal embryos through PGS can effectively avoid chromosomal risks caused by age factors.

2. Clinical data on effectively reducing the risk of abortion

show that about 15%-20% of pregnancies in natural pregnancies end in abortion, of which about 80% are early abortion (within 12 weeks of pregnancy), and chromosomal abnormalities are the primary cause of early abortion, accounting for more than 50%.

The third generation of test-tube babies eliminated embryos with chromosomal abnormalities from the source through pre-transplant chromosome screening, reducing the abortion rate to about 5%-10%. This not only reduces women's physical and psychological trauma, but also avoids the damage caused to the uterus by repeated uterine curettages and protects women's fertility.

3. Blocking genetic diseases and achieving eugenics and

postnatal care is one of the most valuable advantages of the third generation of test-tube babies. For couples carrying single-gene genetic diseases (such as thalassemia, hemophilia, polycystic kidney disease, spinal muscular atrophy SMA, etc.), PGT-M technology can be used to screen healthy embryos that do not carry the pathogenic gene at the embryonic stage., fundamentally avoiding the risk of genetic diseases being passed on to the next generation.

At present, three-generation test tube technology can detect hundreds of monogenic inherited diseases, including autosomal dominant inheritance, autosomal recessive inheritance, X-linked inheritance and other genetic patterns. For families with a family history of genetic diseases, three-generation test tubes are the most direct and effective means to achieve eugenics and postnatal care.

4. Improving the efficiency of assisted pregnancy in elderly women

Elderly age (over 35 years old) is an important factor affecting the success rate of IVF. As women age, not only does the number of eggs decrease, but the quality of eggs also decreases significantly, and the rate of chromosomal abnormalities increases sharply. If you do not transplant PGS directly, it may take multiple attempts to succeed, which is time-consuming and increases the financial burden.

The third generation test tube selects embryos with abnormal chromosomes by screening to ensure that every embryo transplanted is a high-quality embryo with normal chromosomes, thereby reducing the number of transplants and shortening the assisted pregnancy cycle. For older women, time is fertility, and third-generation test-tube technology can help them achieve fertility goals more efficiently within a limited fertility window.

5. Three-generation IVF technology can be used for embryo sex screening

. While screening chromosomes, it can accurately identify the sex chromosomes (XX or XY) of the embryo, thus knowing the gender of the embryo. In some countries where policies allow (such as Thailand, the United States, Georgia, etc.), families with family balance needs can choose the gender of their baby through three generations of test tubes.

It should be noted that in China, selecting XY for non-medical needs is explicitly prohibited by law. If you have relevant needs, you need to go to a country permitted by law. Lelaiwa Consulting Service Center cooperates with many high-end fertility centers in Thailand, the United States, Malaysia and other countries to provide legal XY selection service consultation to families in need.

6. Reduce the risk of multiple pregnancies

In conventional IVF, doctors sometimes recommend transferring 2-3 embryos, which increases the probability of multiple pregnancies. Multiple pregnancy not only increases the risk of complications such as gestational hypertension, diabetes, and premature delivery, but also affects the healthy development of the fetus.

Because the third-generation test tube transfers high-quality embryos that have been screened, a single embryo transfer strategy can be chosen to effectively reduce the risk of multiple pregnancies and achieve the ideal pregnancy outcome of "single, full-term, and healthy."

3. Third generation test tube vs first generation/second generation: Technical comparison is clear at a glance

Le Laiwa professional reminds

that many people mistakenly think that the third generation test tube is" better" than the first generation two, but this is not the case. The third generation test tube adds genetic testing to the first generation/second generation, and not everyone needs to do it. If both spouses have normal chromosomes, no history of genetic diseases, and the woman is young, the first or second generation test tubes can fully meet the needs. Whether it is necessary to make third-generation test tubes, it is recommended to consult a professional doctor and make a comprehensive judgment based on personal circumstances. Lelaiwa Consulting Service Center provides free case assessment services, and you are welcome to scan the code for consultation.

4. Which groups of people are suitable for third-generation IVF?

Although the third-generation IVF technology has obvious advantages, it is not suitable for everyone. According to domestic and foreign guidelines for assisted reproduction, PGT 1 is recommended for the following groups of people

. Elderly women (35 years old and above)have an increase in the rate of chromosome abnormalities in eggs as they age. PGS can screen for normal embryos and reduce the risk of abortion.

2. Ifhigh-quality embryos have not yet been implanted after repeated implantation failure and transplantation twice or more, it is recommended to perform PGS for chromosomal factors.

3. Forthose with 2 or more spontaneous abortions due to recurrent abortion, chromosomal abnormalities in the embryo are the most common cause.

4. Chromosomal abnormality carriershave chromosome number or structure abnormalities in one or both spouses (such as balanced translocation, Roche translocation, etc.).

5. Patients/carriers with monogenic diseasesOne or both spouses have a monogenic disease or have a clear family history of the disease.

6. In men with severe oligospermia, severe oligospermia is often accompanied by an increased rate of sperm chromosome abnormalities, so it is recommended to combine PGT.

7. Families with needs for XY selectioninclude families with sex-linked genetic diseases, children with both needs, etc.(must be carried out in countries permitted by law).

8. Families pursuing eugenics and superior educationhope to ensure the quality of embryos to the greatest extent, reduce pregnancy risks, and achieve eugenics and superior education.

5. Lelaiwa Consulting Service Center: Full-process service guarantee for third-generation test tube

As a professional international assisted reproductive medical consulting service organization, Lelaiwa Consulting Service Center has been deeply involved in the overseas three-generation test tube field for many years, integrating Thailand, the United States, Malaysia, Georgia, Kyrgyzstan, etc. Global high-end reproductive hospital resources provide customers with full-process services from consultation to successful delivery.

1. Global high-quality hospital resources are directly connected to

Lelaiwa and dozens of countries such as Thailand Tanruo International, Wanlai Life and Reproductive Center, IBABY Reproductive Center, Thailand DHC Reproductive Center, Malaysia Alpha, Shengfeng Hospital, USA HRC, IRFC Reproductive Center, etc., Kyrgyzstan IRMC, etc. Internationally renowned reproductive institutions have established official cooperative relationships. All cooperative hospitals hold local formal medical licenses, and their technical level and safety management meet international standards.

2. Professional medical consultants accompany

each client throughout the entire process. Each client is equipped with a dedicated fertility consultant, from pre-consultation, physical examination, hospital selection, doctor appointment, to interpreter escort and itinerary arrangements during overseas medical treatment, to post-transplant follow-up in the first trimester, the entire process is one-on-one service ensures that customers receive professional guidance and caring care in every aspect.

3. Video consultation with overseas doctors

Before deciding to go overseas, Le Laiwa will arrange for the client to conduct a video consultation with overseas reproduction experts. The doctor will conduct a detailed evaluation based on the client's examination report and formulate a personalized elimination promotion plan and PGT testing plan, so that the client can know the entire treatment process before departure.

4. One-stop life service guarantee

Lelaiwa provides one-stop services such as visa processing, air ticket booking, apartment accommodation, medical translation, special bus transfers, and life assistants, so that customers and family members do not have to worry about daily trivial matters while they are overseas, and can fully cooperate with treatment

5. Transparent charging and compliance services

Lelaiwa always adheres to compliance operations. All service fees are transparent and disclosed. Medical expenses are paid directly by customers to the hospital's corporate account. They do not earn medical price differences, do not promise pregnancy success rates, and do not promote illegal services to ensure The legitimate rights and interests of customers are fully protected.

6. Answers to frequently asked questions (Q&A)

Q: How high is the success rate of the third generation of IVF?

Thesuccess rate of the third generation of IVF varies depending on factors such as age, physical condition, and hospital technical level. Generally speaking, women under the age of 35 undergo three generations of test tubes, and the rate is about 40%-50% between 35 and 38 years old; the rate is about 30%-40% between 38 and 40 years old; and the rate is significantly lower for women over 40 years old. It should be noted that the statistical caliber of success rate data varies, and it is recommended to use the complete cycle data officially announced by the hospital. The overseas reproduction centers that Le Laiwa cooperates with will provide real and verifiable success rate data, so you are welcome to consult.

Q: Is making three generations of test tubes harmful to embryos? Will it affect your baby's health?

AThis is a concern for many families. The third generation test tube requires taking a small number of cells from the embryo for testing, a process called "embryo biopsy." The current mainstream biopsy method is blastocyst stage biopsy (the trophectodermal cells of a 5-6-day blastocyst are taken and will develop into the part of the placenta in the future), which will not affect the inner cell mass (the part that will develop into the fetus in the future). A large number of clinical studies and long-term follow-up data show that babies born after PGT testing have no significant differences in birth defects, development, intelligence level, etc. from naturally conceived babies. There are millions of healthy babies born through three generations of test-tube technology around the world, and the safety of the technology has been fully verified.

Q: What is the approximate cost of third-generation IVF? How much more expensive than the first generation?

Thecost of generation A test tube is indeed higher than that of generation A, mainly because of the increased cost of embryo genetic testing. The overall cost varies by country and hospital: the full process cost of the third-generation test tube in Thailand is about RMB 120,000 - 180,000; Malaysia is about RMB 100,000 - 150,000; and the United States is about RMB 200,000 - 300,000. Specific expenses include: expulsion promotion medical expenses, egg retrieval surgery fees, ICSI fees, embryo culture fees, blastocyst culture fees, PGT testing fees (charged based on the number of embryos), embryo transfer fees, cryopreservation fees, etc. Lelaiwa Consulting Service Center provides each customer with a detailed list of expenses to ensure transparent consumption and no hidden charges.

Q: How long does it take to make the third generation test tube? How long will you be abroad?

ATake the third generation test tube in Thailand as an example. A complete cycle usually requires the woman to go to Thailand twice: the first time is the stage of promoting ovulation and egg retrieval, which lasts for about 12-15 days (from the second day of menstruation to 2-3 days after egg retrieval); The second time is the embryo transfer stage, which lasts for about 5-7 days (from the 10th-12th day of menstruation to 3-5 days after transplantation). The man only needs to go on the same day of egg retrieval (abstinence for 3-7 days before sperm retrieval). PGT testing is usually carried out from the embryo culture to the blastocyst stage after egg retrieval. The testing cycle is about 2-4 weeks. During this time, customers can wait for the results in China without having to stay abroad. The specific time schedule will be adjusted according to the individual's menstrual cycle and plan, and Lelaiwa consultant will help you plan your trip in advance.

Q: Can all embryos pass the PGS test? What if none passes?

ANot all embryos can pass the PGS test. The proportion of normal embryos mainly depends on the woman's age and the chromosome status of both sides. Generally speaking, about 60%-70% of women under 30 years old have normal chromosomes in their embryos; about 50% at 35 years old; about 20%-30% at 40 years old; and only 5%-10% over 43 years old. If all the embryos obtained during the first expulsion promotion fail the test, it is necessary to evaluate whether to perform the second expulsion promotion according to the specific circumstances. Lelaiwa Consulting Service Center's medical consultant will estimate the number of normal embryos available for you in advance based on your age, AMH value, number of basal follicles and other indicators, and formulate reasonable treatment expectations and options.

Q: You can also make third-generation test tubes in China, why go overseas?

AThere are indeed some hospitals in China that can carry out third-generation test tube technology, but there are several differences that need to be understood: the first is the limitation of indications. The domestic indications for third-generation test tubes are strictly controlled, and only applications can be made if there are clear chromosomal abnormalities or genetic disease indications; the second is the technical level. Some overseas countries (such as the United States and Thailand) have accumulated richer experience in PGT technology, laboratory equipment, blastocyst culture technology, etc.; The third is policy flexibility. Overseas policies are relatively loose in terms of selecting XY and third-party assisted reproduction; the fourth is the medical experience. Overseas reproduction centers usually adopt an appointment system and one-on-one services, making the medical experience better. Of course, the final choice of where to do it still has to be decided based on the individual's specific circumstances and needs. Lelaiwa Consulting Service Center can provide you with comparative analysis of domestic and foreign hospitals to help you make the most suitable choice.