1. Review of hot events
    Recently, the Tongan District Court in Xiamen, Fujian Province heard a divorce dispute arising from assisted childbirth. Xiao Li (pseudonym) and Xiao Jun (pseudonym) had not conceived a child after two years of marriage. After hospital examination, it was found that Xiao Jun could not give birth normally due to chromosomal abnormalities. The couple decided to use assisted reproductive technologies such as test-tube fertilization to realize their childbearing aspirations.
    ,,.The physical pain and the psychological pressure of repeated failures made it more and more difficult for her to bear. She repeatedly expressed to her husband that she did not want to continue receiving IVF.
    ,,.The talks between the two sides on this issue became more and more tense, and eventually the conflict intensified. Xiaoli sued the court, demanding a divorce, and made it clear that she did not want to continue making test tubes. Xiao Jun disagreed with the divorce and still insisted that she continue to receive assisted reproduction.
    ,,,,,,.Therefore, the court found that the two parties had serious differences due to the choice of fertility concepts and fertility methods and could not be reconciled, resulting in the breakdown of the couple's relationship, and finally ruled that divorce was granted.
This incident has drawn attention from society to the relationship between chromosomal abnormalities and assisted reproduction. It has also helped more people understand the impact of chromosomal abnormalities on fertility, as well as the importance of the couple’s right to make decisions regarding their own reproductive choices during assisted reproduction processes.
2. Chromosomal abnormalities: the invisible killer of in vitro abortion
1.
    1. Types of chromosomal abnormalities
Chromosomal   abnormalities mainly include numerical abnormalities and structural abnormalities
-Abnormal    number: such as Down's syndrome (trisomy 21), Edwards's syndrome (trisomy 18), etc.
-Structural    abnormalities: such as chromosome translocations, inversions, deletions, duplications, etc.
   2. Effect of chromosomal abnormalities on test tubes
   -Fertilization failure: Chromosomal abnormalities in sperm may affect the fertilization process
   -Abnormal development of embryos: Even if fertilization is successful, embryos with abnormal chromosomes may stop dividing during development
   -Implantation failure: It is difficult for embryos with chromosomal abnormalities to successfully implant in the uterus
-Abortion   : Even if implantation is successful, embryos with chromosomal abnormalities are prone to early abortion
   -Fetal malformations: A small number of embryos with chromosomal abnormalities may develop to term, but severe malformations may occur
   3. Analysis of the causes of repeated abortion
   The reasons for repeated abortion (3 or more consecutive spontaneous abortions) are complex, of which chromosomal abnormalities are one of the most common reasons, accounting for more than 50%.
For women who become pregnant through in vitro fertilization technology, although the embryos have been screened, if the male partner has chromosomal abnormalities, it is still possible for the embryo to also have chromosomal issues, which can lead to miscarriage.
3. Detection methods for chromosome abnormalities
   1 .
    1. Pre-pregnancy chromosome testing
    - Karyotype analysis: Traditional chromosome karyotype analysis can detect chromosomal number and structural abnormalities
     - Gene chips: can detect more subtle chromosomal abnormalities
-Whole    exon sequencing: it can detect single gene inherited diseases
    2. Preimplantation genetic testing (PGT)
PGT-A    : Detection of chromosomal abnormalities in embryos
PGT-SR    : Detection of chromosomal structural abnormalities in embryos
PGT-M    : Detection of single-gene inherited diseases in embryos
    4. Response strategies and solutions
    1. genetic counseling
    For couples with a family history of genetic disease or repeated miscarriages, genetic counseling should be conducted to understand the risks and possible solutions for chromosomal abnormalities.
       2. Preimplantation genetic testing (PGT)
    Through PGT technology, embryos with normal chromosomes are selected for transplantation to reduce the risk of abortion.
       3. Essence supply/volunteers
    If the man's chromosome abnormalities are serious, consider using donor sperm; if the woman's chromosome abnormalities are serious, consider using volunteers.
       4. adoption
Adoption    is also an option for couples who cannot obtain healthy offspring through assisted reproductive technology.
5. Legal and ethical thinking
    1.
     1. legal level
    my country's Civil Code stipulates that both spouses have the right to have children and the freedom not to have children. In the above-mentioned cases, the core basis for the court's decision to divorce was that if the woman was still required to continue receiving treatment such as test tube, expulsion promotion, and transplantation even though she had clearly expressed her reluctance to continue receiving assisted reproduction, it would actually infringe on her reproductive autonomy. Rights will also place a further burden on her physical and mental health.
    ,,,,.This judgment reflects respect for and protection of women's reproductive autonomy.
      2. ethical dimensions
    -Reproductive autonomy: Everyone has the right to decide whether and how to have children. This is a basic personal right
-Marital    responsibility: When facing childbearing difficulties, both spouses should understand, support and face each other together, but cannot force each other to accept unwanted childbearing methods on the grounds of marriage
    -Right to know: During assisted reproduction, both parties have the right to understand each other's health status and treatment options
-Right    to choose: Couples have the right to choose suitable childbearing methods based on their own circumstances, including assisted reproduction, adoption, etc.
    6. Expert suggestions
    Reproductive experts suggest that for couples with a history of repeated miscarriages, chromosome tests should be performed in a timely manner to clarify the reasons. If chromosomal abnormalities are found, an appropriate treatment plan should be selected under the guidance of a doctor.
     ,,.Advances in assisted reproductive technologySteps provide couples with chromosome abnormalities with more reproductive options and give them a chance to have healthy offspring.
Conclusion
   In vitro abortion caused by chromosomal abnormalities is a complex problem that requires scientific understanding and correct response .
    ,.Through techniques such as genetic counseling and pre-implantation genetic testing, most couples with chromosomal abnormalities still have a chance to have healthy offspring.
    ,,,.As stated in the court's decision, when a party has clearly expressed its reluctance to continue receiving assisted reproduction, it should not be forced to continue treatment, otherwise it will infringe on its reproductive autonomy and cause further burdens on its physical and physical and mental health.
    ,,,,,.It is hoped that this hot event will attract society's attention to chromosome abnormalities and assisted reproduction, and provide scientific guidance and humanistic care for more families facing similar problems.