1. How does Y chromosome deletion affect fertility?
Y,AZF(AZFa,AZFb,AZFc).If these areas are missing, it can lead to sperm production disorders
·Loss of AZFa region: Testes atrophied, no sperm production, and sperm supply is needed.
· AZFb region deletion: Sperm fail to develop into mature cells at the spermatocyte stage, requiring donor sperm for reproduction.
· AZFc region deletion: This is the most common type (accounting for 70%-80%). It may manifest as oligospermia, weak sperm, or azoospermia. However, it is still possible to obtain sperm through microsurgical sperm extraction.
1.
1. AZFa/AZFb region deletion: sperm donor assisted reproduction
If a complete deletion of the AZFa or AZFb region is diagnosed and the testis cannot produce sperm, it is recommended to achieve fertility through donor artificial insemination (AID) or donor IVF babies.
2. AZFc region deletion: microscopic sperm collection + IVF
Microsperm harvesting can find residual sperm from the testicles and is combined with second-generation in vitro fertilization (ICSI) technology to fertilize the egg. If embryos are successfully obtained, it is recommended to screen healthy embryos through third generation in vitro fertilization (PGD/PGS) to avoid inheriting Y chromosome deletions to the son.
Case reference: Mr. Zhao, 32 years old, suffered fromAZF b+c deletion. However, he managed to obtain sperm through microsurgical sperm extraction, and successfully delivered a healthy female baby.
·Genetic riskassessment
AZFc deletions may be passed on to male descendants, and genetic counseling is needed in advance to choose gender screening (PGD) or cryopreservation of daughter embryos.
The AZFc deletion may be inherited by male offspring. It is necessary to seek genetic counseling in advance, and consider gender screening (PGD) or freezing of the daughter’s embryos.
The sperm count of patients with AZFc deletion may decrease year by year, so it is recommended to treat or cryopreserve sperm as soon as possible.
Patients with AZFc deletion may experience a gradual decrease in sperm count over time. It is recommended to seek treatment as soon as possible or to preserve the sperm through cryopreservation.
Chinese medicine improves sperm quality by soothing liver and invigorating spleen, tonifying kidney and nourishing essence to regulate constitution.
Key to Success and DataSupport

(c) Ovarian function.
Related to ovarian function.)
Genetic Prevention: PGD technology can ensure that the transmission of Y-chromosome deficiencies to sons is completely avoided.
Y chromosome deletion is not a "dead end" for fertility!
Y“”! Through precise genetic testing, advanced test tube technology (such as microscopic sperm harvesting +PGD), and coordinated treatment of traditional Chinese and Western medicine, many families have successfully welcomed healthy babies. Early diagnosis, early intervention and early treatment are the key! If you are facing such problems, it is recommended to see a doctor as soon as possible and develop a personalized plan.
Warm reminder: Men are advised to conduct semen analysis +Y chromosome microdeletion screening before pregnancy to detect early and respond early to protect fertility!
Kind reminder: It is recommended that men undergo semen analysis and Y chromosome microdeletion screening before planning to conceive. Early detection and timely intervention can help ensure healthy fertility!