On July 25, 1978, the world's first test-tube baby Louise Brown was born at Oldham General Hospital in Manchester, England. This breakthrough event was led by Cambridge University scientist Robert Edwards and gynecologist Patrick Stipter, who used in vitro fertilization to help Leslie Brown, who was unable to have children due to fallopian tube disease, successfully conceive. Louise's birth marked a major breakthrough in human assisted reproductive technology. Although it triggered ethical controversy at the beginning, her healthy growth (natural pregnancy in 2006) provided strong proof of the safety of the technology.

Timeline of the World's First Test Tube Baby Birth

United States (December 28, 1981): The first test-tube baby Elizabeth Carr was born at Norfolk General Hospital in Virginia. At the age of 43, she has become a health journalist, marathon runner, and has a son.

Soviet Union (February 7, 1986): A team of doctors in Moscow completed the first test-tube baby of Elena Donzova. She was cultivated by Elena Karinina, an expert in obstetrics and gynecology. In 2007, she gave birth to a male boy through natural childbirth.

France (February 24, 1982): Amandina, the first test-tube baby, was born in the city of Cramar, Paris. Her parents remained anonymous. The baby weighed 3.5 kilograms at birth and was in good health.

Canada (December 25, 1983): Vancouver General Hospital welcomed the first test-tube baby of Robert John Saunderried. His premature birth weight was only 1 kilogram. Parents did not disclose the child's follow-up information to protect privacy.

Australia (June 23, 1980): The Royal Women's Hospital in Melbourne gave birth to the first test-tube baby Candace Toom through in vitro fertilization. She is currently the head of the charity and has children.

Germany (1985): The first test-tube baby Oliver was delivered by Caesarean section at the University Hospital of Erlangen, weighing 4.15 kilograms. The application rate of assisted reproductive technology in Germany has increased year by year, and 1% of more than 700,000 newborns are test-tube babies.

Latin America (1985): Diana Carolina Mendes, the first test-tube baby in Colombia, was born, successfully achieved by Dr. Elgin Lucena after 40 failures, promoting the development of regional reproductive medicine.

Singapore (May 19, 1983): Samuel Lee Jianwei, Asia's first test-tube baby was born in Zhujiao Maternal and Child Hospital. His mother, Professor Huang Rongye, is known as the "father of test-tube babies in Asia." During an interview in 2019, Samuel said that "the identity of test-tube babies has been calmly accepted."

South Korea (February 11, 1985): The first test-tube baby was born at Seoul National University Hospital. Her sister naturally gave birth to a healthy baby girl in 2019 to verify the fertility of test-tube babies.

China (March 10, 1988): Professor Zhang Lizhu's team from the Third Hospital of Beijing Medical University successfully delivered Zheng Mengzhu, the first test-tube baby in the mainland of China. In 2019, she gave birth to a male boy through natural conception, becoming the "second generation of test-tube babies" mother.