Personal profile
Chen Zijiang, female, born in 1959, from Liuyang, Hunan. Graduated from Shandong Medical University in 1989 and was one of the first two doctoral students of Shandong Medical College. Current Shanghai Jiaojiao
Chief expert of the Reproductive Center of Renji Hospital Affiliated to the School of Medicine, Tong University,director and doctoral supervisor of Shanghai Key Laboratory of Assisted Reproduction and Eugenics; Chair Professor of Shandong University, Shan
Chief Expert of the Reproductive Hospital Affiliated to Eastern University, Director of the Women and Children Medical Research Center of Shandong University, Director of the National Assisted Reproduction and Eugenics Engineering Technology ResearchCenter, and Reproductive Medicine Department of the Ministry of Education
Director of the Key Laboratory of Secretion; concurrently serving as the Standing Director and Secretary-General of the International Federation of Reproductive Societies (IFFS). Mainly engaged in reproductive health and birth defects and major reproductive endocrine diseases
The clinical diagnosis, treatment and scientific research of diseaseis a well-known obstetrics and gynecology and reproductive medicine scientist in my country. Elected as an academician of China Academy of Sciences in 2019 and as an academician of the Academy of Sciences of Developing Countries in 2021
Fellow.
Chen Zijiang has successively presided over the National Key R & D Plan, the 973 Project, the 863 Project, and the National Nature Key Project; he has won many awards such as the National Invention Award and the National Science and Technology Progress Award; he has won the title of
Corresponding author The corresponding author has more than300 SCI papers in international high-end journals such as NEJM, Lancet, Nature Cell, PNAS, etc., and has edited more than 10 books; authorized invention specialist
won more than 10 awards; won many honors such as the National Innovation Champion Award, the National May 1st Labor Medal, the He Liang He Li Foundation Science and Technology Progress Award, and the Wu JiepingMedical Award.
has been engaged in clinical diagnosis, treatment and scientific research on obstetrics and gynecology, reproductive health and birth defects for more than 30 years, leading a series of multi-center clinical studies, solving one of the problems in the clinical application of assisted reproduction.
Some key issues
presided over the formulation of a series of specifications such as the "Diagnosis of Polycystic Ovary Syndrome"Standards and the "Diagnosis Guidelines for Infertility"
It explains the etiology and mechanism of major reproductive disorders such as infertility, and reveals the key laws of early development and regulation of human gametes and embryos. Series of results published in N Engl J
MedLancet, Science, Nature and Cell.
nResearch areas
1. Study on the pathogenesis of reproductive endocrine diseases
2. Regulation of oogenesis and embryonic development
3. RCT and cohort study on reproductive disorders
4. Research on prevention and control of birth defects
5. Research and development and transformation application of new reproductive medicine technologies
1. First-level discipline: clinical medicine
2. Secondary subject: Obstetrics and Gynecology
3. Subject direction: Obstetrics and Gynecology/Reproductive Medicine
1. First-level discipline: basic medicine
2. Second-level discipline: Basic Science
3. Subject direction: Cell biology
nHonor rewards
Academician of China Academy of Sciences
nNational Invention Award
National Science and Technology Progress Award
He Liang He Li Science and Technology Progress Award
nNational Innovation Champion Award
Tan Jiazhen Life Sciences Achievement Award
Representative paper
1.Xuepeng Chen#, Yuwen Ke#, Keliang Wu#, Han Zhao#, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao,
Zhenzhen Hou, Hui Liu, Jiang Liu*& Zi-JiangChen*. Key role for CTCF in establishing chromatin structure in human
embryos.& nbsp;Nature. 2019 Dec;576(7786):306-310.
2.Zhuoning Zou, Chuanxin Zhang, Qiuyan Wang , Zhenzhen Hou , Zhuqing Xiong, Feng Kong, Qiujun Wang, Jinzhu Song,
Boyang Liu , Bofeng Liu , Lijuan Wang , FangnongLai, Qiang Fan, Wenrong Tao, Shuai Zhao, Xiaonan Ma, Miao Li, Keliang
Wu, Han Zhao*, Zi-Jiang Chen*, Wei Xie*. Translatome and transcriptome co-profiling reveals a roleof TPRXs in human
zygotic genome activation. Science. 2022 Oct 7;378(6615):abo7923.
3.Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou,
Dongdong Fan, Yong Tian, Han Zhao, Jianqiao Liu*, Zi-
Jiang Chen*, Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and its Association with Evolution. Cell.& nbsp;
2018 Mar 22;173(1):248-259.e15.
4.Hanni Ke, Shuyan Tang, Ting Guo, Dong Hou, Xue Jiao, Shan Li, Wei Luo, Bingying Xu, Shidou Zhao, Guangyu Li, Xiaoxi
Zhang, Shuhua Xu, Lingbo Wang, Yanhua Wu,Jiucun Wang, Feng Zhang*, Yingying Qin*, Li Jin*, Zi-Jiang Chen*. Landscape
of pathogenic mutations in premature ovarian insufficiency. Nature Medicine. 2023, In press.2023 Feb 2.doi:
10.1038/s41591-022-02194-3. Online ahead of print.
5.Junhao Yan#, Yingying Qin#, Han Zhao#, Yun Sun#, Fei Gong#, Rong Li#, Xiaoxi Sun#, Xiufeng Ling#, Hong Li#, … ,
Heping Zhang, Richard S Legro, Zi-Jiang Chen*.
Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021 Nov 25;385(22):2047-2058.
6.Yuhua Shi, Yun Sun, Cuifang Hao, Heping Zhang, Daimin Wei, Yunshan Zhang, Yimin Zhu, Xiaohui Deng, Xiujuan Qi, Hong
Li, Xiang Ma, Haiqin Ren, Yaqin Wang, DanZhang, Bo Wang, Fenghua Liu, Qiongfang Wu, Ze Wang, Haiyan Bai, Yuan Li, Yi
Zhou, Mei Sun, Hong Liu, Jing Li, Lin Zhang, Xiaoli Chen, Songying Zhang, Xiaoxi Sun,Richard S. Legro, and Zi-Jiang Chen*.
Frozen versus Fresh Embryo Transfer in Ovulatory Women. N Engl J Med, 2018 Jan 11; 378:126-36.
7.Yingying Qin, Feng Zhang, Zi-Jiang Chen*. BRCA2 in Ovarian Development and Function. N Engl J Med. 2019; 380:1086-
1087.
8.Zi-Jiang Chen*, Yuhua Shi, Yun Sun, Bo Zhang, Xiaoyan Liang, Yunxia Cao, Jing Yang, Jiayin Liu, Daimin Wei, Ning Weng,
Lifeng Tian, Cuifang Hao, Dongzi Yang, FengZhou, Juanzi Shi, Yongle Xu, Jing Li, Junhao Yan, Yingying Qin, Han Zhao,
Heping Zhang, Richard S. Legro. Fresh versus Frozen Embryos for Infertility in Polycystic OvarySyndrome. N Engl J Med,
2016 Aug 11; 375(6):523-33.
9.Daimin Wei, Jia-Yin Liu, Yun Sun, Yuhua Shi, Bo Zhang, Jian-Qiao Liu, Jichun Tan, Xiaoyan Liang, Yunxia Cao, Ze Wang,
Yingying Qin, Han Zhao, Yi Zhou, Haiqin Ren,Guimin Hao, Xiufeng Ling, Junzhao Zhao, Yunshan Zhang, Xiujuan Qi, Lin
Zhang, Xiaohui Deng, Xiaoli Chen,Yimin Zhu, Xiaohong Wang, Li-Feng Tian, Qun Lv, Xiang Ma,Heping Zhang, Richard S
Legro, Zi-Jiang Chen*. Frozen versus fresh single blastocyst transfer in ovulatory women: a multicenter, randomized
controlled trial. Lancet. 2019Mar 30;393(10178):1310-1318.
10.Yongyong Shi, Han Zhao, Yuhua Shi, Yunxia Cao, Dongzi Yang, Zhiqiang Li,Bo Zhang, Xiaoyan Liang, Tao L, Jianhua
Chen, Jiawei Shen, Junzhao Zhao,Li You, Xuan Gao,
Dongyi Zhu, Xiaoming Zhao, Ying Yan, Yingying Qin, Wenjin Li, Junhao Yan, Qingzhong Wang, Junli Zhao, Ling Geng,
Jinlong Ma, Yueran Zhao,Guang He, Aiping Zhang,
Shuhua Zou, Aijun Yang, Jiayin Liu, Weidong Li, Baojie Li, Chunling Wan, Ying Qin, Juanzi Shi, Jing Yang, Hong Jiang, Jin-e
Xu, Xiujuan Qi, Yun Sun,Yajie Zhang, Cuifang
Hao, Xiuqing Ju, Dongni Zhao, Chun-e Ren, Xiuqing Li, Wei Zhang, Yiwen Zhang, Jiangtao Zhang, Di Wu, Changming Zhang,
Lin He*, and Zi-Jiang Chen*. Genome-wideassociation study identifies eight new risk loci for polycystic ovary syndrome.
Nature Genetics. 2012; 44(9): 1020-5.
11.Keliang Wu, Cuiqing Zhong, Tailai Chen, Xiaoyu Zhang, Wenrong Tao, Jingye Zhang, Hongchang Li, Han Zhao*, Jinsong
Li* and Zi-Jiang Chen*..Polar bodies are efficientdonors for reconstruction of human embryos for potential mitochondrial
replacement therapy. Cell Research. 2017 Aug; 27(8):1069-1072.
12.Tailai Chen, Yuehong Bian, Xiaoman Liu, Shigang Zhao, Keliang Wu, Lei Yan, Mei Li, Zhenglin Yang, Hongbin Liu, Han
Zhao*, Zi-Jiang Chen*. A Recurrent MissenseMutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility. Am J
Hum Genet. 2017 Sep 7; 101(3):459-465.
