Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, PhD, Associate Researcher.

Education background

Received a Doctor of Science from Fudan University in 2014 and engaged in postdoctoral research at the School of Medicine of Shanghai Jiao Tong University from 2014 to 2016

The main research interests are reproductive endocrinology and cellular molecular biology.

Research Results

More than 30 SCI papers have been published, including 9 first authors or corresponding authors (2 papers in District 1, 4 papers in District 2, and 3 papers in District 3; a single paper has a higher impact factor of 18.639), including

Endocr Rev, Sci Signal, FASEB J, Clin Sci and Endocrinology, etc.; chaired a National Natural Science Foundation of China youth project and participated as a principal researcher

has cooperated with many National Natural Science Foundation projects (including key projects) and national key R & D plans; has won the Elsevier Award of the International Placenta Society, and has also been involved in international reproduction many times

Oral reports were delivered at international and domestic conferences such as the Annual Meeting of the Research Society (SRI), the Annual Meeting of the International Placenta Society (IFPA), and the Annual Meeting of Reproductive Biology of the Zoological Society of China.

tResearch direction:

Reproductive Endocrinology

Research content: 1. Research on the pathogenesis of pregnancy-related diseases (such as preterm labor, IUGR, etc.)

         2. Study on the pathogenesis of polycystic ovary syndrome (PCOS)

Representative papers:

Wang Wangsheng, Sun Gang. Membranes: Degenerated tissue or functional tissue? Chinese Journal of Perinatal Medicine, 2019, 22 (10): 698-703. (Invited commentary)

Wang WS#*, Li WJ#, Wang YW, Wang LY, Mi YB, Lu JW, Lu Y, Zhang CY, Sun K*. Involvement of serum amyloid A1 in the

 rupture of fetal membranes through induction of collagen I degradation. Clinical Science. 2019; 133 (3): 515-530 (#Common No.

and co-corresponding author) (IF=5.220)

Wang YW#, Wang WS#*, Wang LY, Bao YR, Lu JW, L Y, Zhang CY, Li WJ, Sun K*, Yin H*. Extracellular matrix remodeling

 effects of serum amyloid A1 in the human amnion: implications for fetal membrane rupture. Am J Reprod Immunol. 2019;

 81(1):e13073. (#Common First and Common Corresponding Author) (IF=2.745)

Wang LY#, Wang WS#, Wang YW, Lu JW, Lu Y, Zhang CY, Li WJ, Sun K, Yin H. Drastic induction of MMP-7 by cortisol in

 human amnion fibroblasts: implications for membrane rupture at parturition. Faseb J 2019; 33(2):2770-2781. (#Common First Work

) (IF=5.595)

Wang WS, Chen ZJ, Myatt L, Sun K. 11β-HSD1 in human fetal membranes as a potential therapeutic target for preterm birth.

 Endocrine Reviews, 2018; 39(3):241-260. (IF=18.639)

Li WJ#, Wang WS#, Zuo RJ, Liu C, Shu Q, Ying H, Sun K. Induction of pro-inflammatory genes by serum amyloid A1 in

 human amnion fibroblasts. Scientific reports 2017; 7(1):693. (#Co-First Author) (IF=4.609)

Wang WS, Liu C, Sun K. Induction of amnion epithelial apoptosis by cortisol via tPA/Plasmin System. Endocrinology 2016;

157: 4487-4498. (IF=4.224)

Wang WS, Guo CM, Liu C, Li WJ, Myatt L Sun K. Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by

 cortisol in the human amnion at parturition. Sci Signal 2015; 8 (400): ra106. (Cover paper, Focus Commentary) (IF=7.251)

Wang WS, Liu C, Li WJ, Zhu P, Li JN, Sun K. Involvement of CRH and hCG in the induction of aromatase by cortisol in human

 placental syncytiotrophoblasts. Placenta 2014; 35(1):30-36. (Recommended by MDLinx) (IF=3.011)

Wang WS, Li JN, Ge YC, Li WJ, Shu Q, Guan H, Yang K, Myatt L, Sun K. Cortisol induces aromatase expression in human

 placental syncytiotrophoblasts through the cAMP/Sp1 pathway. Endocrinology 2012; 153(4):2012-2022. (IF=4.224)