tResearch direction:

Reproductive Endocrinology

2 Research on the regulatory mechanism of female reproduction and disease, using gene knockout and conditional gene knockout mouse models, mouse ovarian transplantation, patient plasma and placental specimen bank analysis

Analysis, focusing on the pathogenesis and regulatory pathways of major pregnancy diseases such as preeclampsia, recurrent abortion, and infertility.

has been studied in Nature Medicine, Hypertension, Theriogenology, Biology of Reproduction, Reproduction, Endocrinology, Development Growth and Growth Differentiation, Stem Cell Development

Yu, Journal of Hypertension, Journal of Cell Biochemistry, Journal of Molecular Endocrinology, Journal of Gynecologic Endocrinology, Journal of Reproduction and Development, Reproductive Biology and Endocrinology

and other journals published or accepted 36 first and corresponding author papers. Among them, the article published in "Nature Medicine"(Nat Med. 2013;19:1061-1066) was reviewed by

Special attention was paid to the research results. The magazine distributed relevant review articles (commentary: Nat Med. 2013;19:968-969) and recorded a podcast

(podcast)(website: http://www.nature.com/multimedia/podcast/nm/nm-2013-08-06.mp3), Science magazine also selected it in August

Comment on Editor's Choice (EDITORS'CHOICE: Science 2013;341:823).

1. Ma Jin, Yang Jieqiong, Lu Shijian, Sun Yun, Chen Zijiang, Zhang Cong *. Dysfunction of BNIP3 in decidua and the pathogenesis of preeclampsia. Journal of Hypertension.

2019. Pressing.

2. Lu Shijian, Wang Na, Ma Jin, Li Weiping, Chen Zijiang, Cong Zhang *. Down-regulation of the circadian gene BMAL1 that causes impaired decidualization contributes to recurrent abortion in humans. Sheng

Zoology. 2019 (101) 1, July, 138 - 147.

3. Zheng Min, Zuo Gaoge, Tong Jing, Chen Zijiang, Li Weiping, Cong Zhang *. Elevated melatonin concentrations in follicles are associated with ovarian hyperstimulation syndrome (OHSS) and CAN

is an important predictor of OHSS. Gynecology and obstetrics. 2019. 2019 (299):1151–1158. https://doi.org/10.1007/s00404-018-4994-z.

4. Lu Shijian, Wang Na, Lu Hong, Yang Jieqiong, Liu Jianwei, Wei-Ping Li*, Cong Zhang* and Zi-Jiang Chen*. Attenuation of trophoblastic invasion caused by down-regulation of EZH2

Attack is involved in the pathogenesis of recurrent abortion in humans. Molecular therapy-nucleic acid. March 1, 2019;14: 377-387.doi: 10.1016/j.omtn.2018.12.011.

5. Shi Feifei #, Li Hua, Wang Enling, Chen Zijiang, Zhang Cong * Melatonin reduces 2 cell block through the non-receptor pathway in mice. Journal of Cell Biochemistry. 2018

November;119(11):9380-9393.DOI: 10.1002/jcb.27255.

6. Yang Jieqiong #, Zhang Yachao, Tong Jing, Lu Hong, Zhang Cong *, Chen Zijiang *. Dysfunction of DDIT4 in decidua and the pathogenesis of preeclampsia. Reproductive biology.

2018, 98(6), 821-833.DOI: 10.1093/biolre/ioy038

7. Lu Hong #, Tong Jing, Yang Jieqiong, Lu Shijian, Li Weiping *, Zhang Cong *, Chen Zijiang *. The dysregulated pseudogene HK2P1May causes preeclampsia through impairment as hexose

The ceRNA of Kinase 2 contributes to degeneration. Hypertension. 2018;71: 648-658.

8. Zhang Yachao #, Yang Jieqiong #, Lu Shijian, Zhao Dongqin, Chen Jiangziyi *, Li Weiping *, Zhang Cong *. Down-regulation of SP1 and p300 by molly beans is associated with severe preeclampsia. Period

Journal of Molecular Endocrinology. February 2018;60(2):133-143.

9. Liu Linlin #, Yang Man, Wang Naiqiang, Li Li, Chen Zijiang and Zhang Cong *. New insights into low fertility in transplanted women: Immunosuppressive drug FK506 causes calcium leakage and

The oocyte is activated before fertilization. Journal of Cell Biochemistry. March 2018;119(3): 2964-2977.

10. Zhang Xinlian #, Liu Lisheng, Wang Naiqiang, Chen Zijiang and Zhang Cong *. Role of HDL and LDL in maintenance mouse ovarian steroids. Reproductive biology. January 2017

1;97(6):862-872.

11. Tong Jing #, Zhao Weixiu, Lu Hong, Li Weiping, Chen Zijiang, Zhang Cong *. Transcriptomic analysis of severe human decidua detected preeclampsia by RNA sequencing. Cell Journal

Biochemistry. 2018. 119:607-615. (If 3.085)

12. Zhang Kaiyue #, Zhong Wanxia, Li Weiping *, Chen Zijiang * and Zhang Cong *.miR-15a-5p levels are associated with poor ovarian response in human follicular fluid. reproduce. 2017 10

Month;154(4):483-496.

13. Tong Jing #, Sheng Shile, Sun Yun, Li Huihui, Li Weiping *, Zhang Cong * and Chen Zijiang *. Melatonin levels in follicular fluid are a result of IVF and a prediction of ovarian reserve

prepared markers. reproduce. April 2017;153(4):443-451.

14. Zhang Dongmei #, Chang Xinlian, Bai Jing, Chen Zijiang, Li Weiping, Zhang Cong *. Study of cyclooxygenase 2 in humans: decidua of preeclampsia. Reproductive biology. 2016

September; 95(3):56: 1-8.

15. Wang Guiping #, Zhang Zhaohang #, Chen Cheng #, Zhang Yachao #, Zhang Cong *. WNT4/WNT5A dysfunction in decidua: Possible role in the pathogenesis of preeclampsia. High blood

Press magazines. 2016. April;34(4):719-727

16. Guo Tao #, Zhang Liang, Cheng Dong, Liu Tao, An Liguo, Li Weiping *, Zhang Cong *. Low-density lipoprotein receptors affect fertility in female mice. Reproduction, fertility and

Development. 2015;27(8): 1222-1232.

17. Guo Cui #, Meng Xiaoqian, Bai Jing, Chen Cheng, Liu Tao, Liu Tao, Liu Shuzhen, Zhang Cong*, Li Wei-Ping* expression and localization in mouse ovary

Transcription factors SNAIL and SLUG in preimplantation embryos. Cell tissue research. 2014; 358(2):585–595.

19. Zhang Ting #, Dai Pengyuan #, Cheng Dong, Zhang Liang, Chen Jiangziting, Meng Xiaoqian, Zhang Fumiao, Han Xiaoying, Liu Jianwei, Pan Jie, Yang Guiwen, Zhang Cong *. Obesity occurs

There was a slight effect on mouse fertility in apolipoprotein E knockout mice. reproduce. 2014;147 :141–151.

20. Zhang Cong #, Big Michael J, Dugawati Raj, DeMeo Francesco J, Lydon John P, Schoonjans Kristina, Kovanci Ertug and

Murphy Bruce D. Liver receptor homolog-1 is crucial for pregnancy. Natural medicine. 2013;19(8):1061-1066.