Core resume Professor Themis Mantzavinos is one of the founders of the field of assisted reproduction in Greece. In his early years, he received systematic training in IVF technology in the United States. He studied from Howard Jones and Georgeanna Jones, pioneers in the field of assisted reproduction in the United States, and participated in the cultivation of the first IVF in the United States. In 1987, he successfully cultivated the first test-tube baby using egg donation in Greece, marking the realization of this technology in Greece. As the scientific and technical director of IOL Group, he is not only a leader in clinical practice, but also deeply involved in the construction of Greek policies related to assisted reproduction and is a member of the Greek third-party legislative expert committee on legalizing assisted pregnancy. Technical expertise and industry contribution Professor Themis Mantzavinos 'technical expertise is reflected in transforming cutting-edge reproductive technologies into reliable clinical applications. Professor Themis Mantzavinos's technical expertise is reflected in translating cutting-edge reproductive technologies into reliable clinical applications.The IOL Reproductive Center under his leadership is one of the first clinical institutions in the European Union to receive formal approval to apply cytoplasmic transfer technology (i.e., the fourth generation of IVF technology). This technology aims to improve the activity of aging eggs by modifying the egg cytoplasm, providing a new solution for elderly women and poor egg quality. In addition, he also has deep attainments in technical fields such as preimplantation genetic diagnosis (PGD/PGS), which can effectively screen embryonic chromosomal abnormalities and monogenic inherited diseases